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EA-89-YM35

Chemical Structure : EA-89-YM35

CAS No.:

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EA-89-YM35 (BRD9 inhibitor EA-89)

Catalog No.: PC-49152Not For Human Use, Lab Use Only.

BRD9 inhibitor EA-89 is a potent and selective inhibitor that binds to BRD9 in a novel way.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BRD9 inhibitor EA-89 is a potent and selective inhibitor that binds to BRD9 in a novel way.
    EA-89 binds to the acetyl lysine pocket similar to other known bromodomain chemotypes, forming a direct hydrogen bond with the conserved Asn100.
    EA-89 produces a strongly selective profile across a subset of leukemia lines with no impact on the viability of THP-1, HEL, or HCT116.

    Physicochemical Properties

    M.Wt 594.789
    Formula C31H38N4O4S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-7-(3-methyl-1-(piperidin-4-ylmethyl)-1H-indol-5-yl)-4-oxo-5-propyl-4,5-dihydrothieno[3,2-c]pyridine-2-carboxamide

    References

    1. Ellen Weisberg, et al. Blood Cancer J. 2022 Jul 19;12(7):110.

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