CDD-956 | BET BD1 inhibitor | Probechem Biochemicals

Chemical Structure : CDD-956

CDD-956 (CDD956)

Catalog No.: PC-38776Not For Human Use, Lab Use Only.

CDD-956 is a highly potent, selective BET bromodomain 1 (BET BD1) inhibitor with IC50 of 2.1 and 4.4 nM for BRDT-BD1 and BRD4-BD1 respectively, with high selectivity (>500-fold) over BET BD2 proteins.

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Biological Activity

CDD-956 is a highly potent, selective BET bromodomain 1 (BET BD1) inhibitor with IC50 of 2.1 and 4.4 nM for BRDT-BD1 and BRD4-BD1, respectively, with high selectivity (>500-fold) over BET BD2 proteins.
CDD-956 is more metabolically stable compared with JQ1 and CDD-787.
CDD-956 exhibits picomolar inhibition against BRD2-BDT1 (IC50, 310 pM), BRD3-BD1 (IC50, 180 pM), BRD4-BD1 (IC50, 440 pM), and BRDT-BD1 (IC50, 330 pM), respectively, in the bromoKdELECT assays.
CDD-956 inhibited cell viability of MV4;11 and MOLM-13 cells with IC50 of 20.7 nM and 50.4 nM, respectively.
CDD-956 induced G1 arrest and apoptosis in both MV4;11 and MOLM-13 cells, suppressed MYC expression in both cell lines.

Physicochemical Properties

M.Wt	565.674
Formula	C33H35N5O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(3-(1-(2-(4-methyl-2-oxo-1,2-dihydroquinolin-6-yl)acetyl)piperidin-4-yl)-1-(methylamino)-1-oxopropan-2-yl)-5-phenylpicolinamide

References

1. Modukuri RK, et al. Proc Natl Acad Sci U S A. 2022 May 31;119(22):e2122506119.

CDD-956 (CDD956)

Biological Activity

Physicochemical Properties

References

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