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Chemical Structure : CDD-956
Catalog No.: PC-38776Not For Human Use, Lab Use Only.
CDD-956 is a highly potent, selective BET bromodomain 1 (BET BD1) inhibitor with IC50 of 2.1 and 4.4 nM for BRDT-BD1 and BRD4-BD1 respectively, with high selectivity (>500-fold) over BET BD2 proteins.
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CDD-956 is a highly potent, selective BET bromodomain 1 (BET BD1) inhibitor with IC50 of 2.1 and 4.4 nM for BRDT-BD1 and BRD4-BD1, respectively, with high selectivity (>500-fold) over BET BD2 proteins.
CDD-956 is more metabolically stable compared with JQ1 and CDD-787.
CDD-956 exhibits picomolar inhibition against BRD2-BDT1 (IC50, 310 pM), BRD3-BD1 (IC50, 180 pM), BRD4-BD1 (IC50, 440 pM), and BRDT-BD1 (IC50, 330 pM), respectively, in the bromoKdELECT assays.
CDD-956 inhibited cell viability of MV4;11 and MOLM-13 cells with IC50 of 20.7 nM and 50.4 nM, respectively.
CDD-956 induced G1 arrest and apoptosis in both MV4;11 and MOLM-13 cells, suppressed MYC expression in both cell lines.
| M.Wt | 565.674 | |
| Formula | C33H35N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Modukuri RK, et al. Proc Natl Acad Sci U S A. 2022 May 31;119(22):e2122506119.
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