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YEATS4 binder 4d

Chemical Structure : YEATS4 binder 4d

CAS No.: 3034365-92-6

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YEATS4 binder 4d

Catalog No.: PC-49600Not For Human Use, Lab Use Only.

YEATS4 binder 4d is a potent, selective small-molecule epigenetic reader YEATS4 binder with Ki of 33 nM, >10-fold selectivity over YEATS1, 2 and 3.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    YEATS4 binder 4d is a potent, selective small-molecule epigenetic reader YEATS4 binder with Ki of 33 nM, >10-fold selectivity over YEATS1, 2 and 3.
    YEATS4 binder 4d directly binds to YEATS4 at the lysine acetylation recognition site of the YEATS domain.
    YEATS4 binder 4d engages YEATS4 with nanomolar potency in a whole-cell nanoluciferase bioluminescent resonance energy transfer assay (IC50=170 nM).

    Physicochemical Properties

    M.Wt 412.58
    Formula C24H36N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-ethyl-3-((3R,4S)-1-((1-hydroxycyclohexyl)methyl)-3-methylpiperidin-4-yl)-2-methylpyrazolo[1,5-a]pyridine-6-carboxamide

    References

    1. Allyn T Londregan, et al. J Med Chem. 2022 Dec 23. doi: 10.1021/acs.jmedchem.2c01421.

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