| Cat. No. |
Product Name |
Information |
| PC-42090 |
GSK-6853
BRPF1 inhibitor
|
GSK-6853 (GSK6853) is a potent, highly selective and cell-active BRPF1 bromodomain inhibitor with TR-FRET pIC50 of 8.1. |
| PC-42168 |
CPI-637
CBP/p300 inhibitor
|
A potent and selective, cell-active CBP/EP300 bromodomain inhibitor with CBP BRET EC50 of 0.03 uM. |
| PC-43808 |
I-BET726
BET inhibitor
|
I-BET726 (GSK1324726A) is a potent and selective inhibitor of BET bromodomain with IC50 of 41 nM/31 nM/22 nM for BRD2/BRD3/BRD4 respectively. |
| PC-42230 |
TPOP146
CBP/p300 inhibitor
|
TPOP146 is a potent and selective CBP/p300 bromodomain inhibitor with Kd of 134 nM for CBP bromodomain, displays excellent selectivity over other bromodomains (>30-fold over BRD4 (1)). |
| PC-42029 |
Mivebresib
BET inhibitor
|
Mivebresib (ABBV-075) is a potent and orally available BET bromodomain inhibitor with Ki of 1.0, 12.2, 1.5, and 2.2 nM for BRD2, BRD3, BRD4 and BRDT, respectively. |
| PC-23522 |
XY221
BRD4 BD2 inhibitor
|
XY221 is a potent, BRD4 BD2-selective inhibitor with IC50 of 5.8 nM, >600-fold selective over BRD4 BD1 and 9–32-fold over BRD2/3/T BD2. |
| PC-23412 |
SR-C-107 (R)
ENL YEATS inhibitor
|
SR-C-107 (R) is a highly potent YEATS domain-containing protein ENL (Eleven-Nineteen-Leukemia) with IC50 of 40 nM, binding KD of 144 nM. |
| PC-22992 |
Y06014
BET inhibitor
|
Y06014 is a selective BRD4(1) inhibitor with IC50 of 4.87 uM. |
| PC-22925 |
GSK2801
BAZ2A/B inhibitor
|
GSK2801 is a potent, selective and cell active acetyl-lysine competitive inhibitor of BAZ2A and BAZ2B bromodomains with KD values of 136 and 257 nM for BAZ2B and BAZ2A, respectively. |
| PC-22528 |
I-BET469
BET inhibitor
|
I-BET469 is a potent, selective pan-BET bromodomain inhibitor with pIC50 of 7.9 for BRD4 BD1, >5000-fold selective over BAZ2A. |
| PC-22527 |
I-BET787
BET inhibitor
|
I-BET787 (GSK3535787) is potent, efficient pan-BET bromodomain inhibitor with pIC50 of 7.1/5.9 for BRD4 BD1/BD2, respectively. |
| PC-22485 |
Y08284
CBP/p300 inhibitor
|
Y08284 is a potent, selective CBP/p300 bromodomain inhibitor with IC50 of 4.21 nM (CBP bromodomain) in HTRF assays. |
