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Chemical Structure : BAY-850
CAS No.: 2099142-76-2
Catalog No.: PC-60022Not For Human Use, Lab Use Only.
BAY-850 (BAY 850, BAY850) is a potent, isoform selective, cellularly active ATAD2 bromodomain inhibitor with binding IC50 of 166 nM in TR-FRET assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $398 | In stock | |
| 10 mg | $658 | In stock | |
| 25 mg | $1180 | In stock | |
| 100 mg | Get quote |
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BAY-850 (BAY 850, BAY850) is a potent, isoform selective, cellularly active ATAD2 bromodomain inhibitor with binding IC50 of 166 nM in TR-FRET assay; shows no inhibitory activity in a panel of 354 kinases and only modest effects on a few GPCRs; displaces a tetra-acetylated H4 peptide with an IC50 of 22 nM, and the tetra-acetylated peptides with IC50 of 115 nM; pecifically induces ATAD2 bromodomain dimerization and prevents interactions with acetylated histones in vitro, as well as with chromatin in cells.
| M.Wt | 654.252 | |
| Formula | C38H44ClN5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-((R)-1-(((1s,4S)-4-aminocyclohexyl)amino)-3-(4-cyanophenyl)propan-2-yl)-2-chloro-4-methoxy-5-(5-((((R)-1-(p-tolyl)ethyl)amino)methyl)furan-2-yl)benzamide |
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1. Fernández-Montalván AE, et al. ACS Chem Biol. 2017 Nov 17;12(11):2730-2736.
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