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Chemical Structure : I-BRD9
CAS No.: 1714146-59-4
Catalog No.: PC-45582Not For Human Use, Lab Use Only.
I-BRD9 is the first selective cellular chemical probe inhibitor for BRD9 with pIC50 of 7.3.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
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I-BRD9 is the first selective cellular chemical probe inhibitor for BRD9 with pIC50 of 7.3.
I-BRD9 displays 700-fold selectivity over the BET family and 200-fold over the highly homologous BRD7.
I-BRD9 decreases cell proliferation, G1-arrest and apoptosis in rhabdoid tumor cells.
I-BRD9 shows synergistic inhibitory effects on cell proliferation combined with doxorubicin or carboplatin.
| M.Wt | 497.5536 | |
| Formula | C22H22F3N3O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 15.5 mg/mL |
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| Chemical Name/SMILES |
Thieno[3,2-c]pyridine-2-carboximidamide, 5-ethyl-4,5-dihydro-4-oxo-N-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-7-[3-(trifluoromethyl)phenyl]- |
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1. Theodoulou NH, et al. J Med Chem. 2016 Feb 25;59(4):1425-39.
2. Krämer KF, et al. Int J Mol Sci. 2017 Jul 16;18(7). pii: E1537.
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