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Chemical Structure : BI-9564
CAS No.: 1883429-22-8
Catalog No.: PC-42110Not For Human Use, Lab Use Only.
BI-9564 (BI9564) is a potent, selective, cell-permeable and noncytotoxic BRD9 bromodomain inhibitor with IC50 of 75 nM, Kd of <20 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $58 | In stock | |
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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BI-9564 (BI9564) is a potent, selective, cell-permeable and noncytotoxic BRD9 bromodomain inhibitor with IC50 of 75 nM, Kd of <20 nM.
BI-9564 displays 45-fold selectiveity over BRD7, and >5,000-fold over BRD4-BD1, BRD4-BD2, and BRD2-BD1.
BI-9564 blocks EOL-1 cell proliferation with EC50 of 0.8 uM, and displays antitumor activity in an AML xenograft model.
| M.Wt | 353.4149 | |
| Formula | C20H23N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 7.2 mg/mL (Need warming) |
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| Chemical Name/SMILES |
4-(4-((dimethylamino)methyl)-2,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one |
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1. Martin LJ, et al. J Med Chem. 2016 May 26;59(10):4462-75.
2. Krämer KF, et al. Int J Mol Sci. 2017 Jul 16;18(7). pii: E1537.
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