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BI-9564

Chemical Structure : BI-9564

CAS No.: 1883429-22-8

BI-9564 (BI 9564, BI9564)

Catalog No.: PC-42110Not For Human Use, Lab Use Only.

BI-9564 (BI9564) is a potent, selective, cell-permeable and noncytotoxic BRD9 bromodomain inhibitor with IC50 of 75 nM, Kd of <20 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BI-9564 (BI9564) is a potent, selective, cell-permeable and noncytotoxic BRD9 bromodomain inhibitor with IC50 of 75 nM, Kd of <20 nM.
BI-9564 displays 45-fold selectiveity over BRD7, and >5,000-fold over BRD4-BD1, BRD4-BD2, and BRD2-BD1.
BI-9564 blocks EOL-1 cell proliferation with EC50 of 0.8 uM, and displays antitumor activity in an AML xenograft model.

Physicochemical Properties

M.Wt 353.4149
Formula C20H23N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 7.2 mg/mL (Need warming)

Chemical Name/SMILES

4-(4-((dimethylamino)methyl)-2,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one

References

1. Martin LJ, et al. J Med Chem. 2016 May 26;59(10):4462-75.

2. Krämer KF, et al. Int J Mol Sci. 2017 Jul 16;18(7). pii: E1537.

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