PF-CBP1 hydrochloride is a potent, highly selective inhibitor of the CBP and p300 bromodomains with IC50 of 125 nM and 363 nM, respectively.
PF-CBP1 displays >100-fold selectivity for the bromodomain of CBP over those of BRD4 and a panel of other proteins.
PF-CBP1 reduces the expression of inflammatory cytokines by LPS-stimulated primary macrophages, also suppresses the expression of RGS4 in primary cortical neurons.
