JQ-1 carboxylic acid |CAS:202592-23-2 Probechem Biochemicals

Chemical Structure : JQ-1 carboxylic acid

CAS No.: 202592-23-2

JQ-1 carboxylic acid ((+)-JQ-1 carboxylic acid)

Catalog No.: PC-45994Not For Human Use, Lab Use Only.

JQ-1 carboxylic acid is an inhibitor of bromodomain and extra terminal domain (BET) family proteins with Kd of 128, 59.5, 49.0, and 190 nM for JQ1 binding to bromodomains of BRD2, BRD3, BRD4, and BRDT, respectively, blocking their interaction with acetylated histones.

Packing	Price	Stock
25 mg	$128	In stock
50 mg	$188	In stock
100 mg	$288	In stock
200 mg		Get quote
1 g		Get quote

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Biological Activity

JQ-1 carboxylic acid is an inhibitor of bromodomain and extra terminal domain (BET) family proteins with Kd of 128, 59.5, 49.0, and 190 nM for JQ1 binding to bromodomains of BRD2, BRD3, BRD4, and BRDT, respectively, blocking their interaction with acetylated histones.
JQ-1 carboxylic acid is a chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis.

Physicochemical Properties

M.Wt	400.8819
Formula	C19H17ClN4O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO
Chemical Name/SMILES	6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, (6S)-

References

1. Filippakopoulos P, et al. Nature. 2010 Dec 23;468(7327):1067-73.

2. Mertz JA, et al. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16669-74.

3. Dawson MA, et al. Nature. 2011 Oct 2;478(7370):529-33.

JQ-1 carboxylic acid ((+)-JQ-1 carboxylic acid)

Biological Activity

Physicochemical Properties

References

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