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Chemical Structure : JQ-1 carboxylic acid
CAS No.: 202592-23-2
Catalog No.: PC-45994Not For Human Use, Lab Use Only.
JQ-1 carboxylic acid is an inhibitor of bromodomain and extra terminal domain (BET) family proteins with Kd of 128, 59.5, 49.0, and 190 nM for JQ1 binding to bromodomains of BRD2, BRD3, BRD4, and BRDT, respectively, blocking their interaction with acetylated histones.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $128 | In stock | |
| 50 mg | $188 | In stock | |
| 100 mg | $288 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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JQ-1 carboxylic acid is an inhibitor of bromodomain and extra terminal domain (BET) family proteins with Kd of 128, 59.5, 49.0, and 190 nM for JQ1 binding to bromodomains of BRD2, BRD3, BRD4, and BRDT, respectively, blocking their interaction with acetylated histones.
JQ-1 carboxylic acid is a chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis.
| M.Wt | 400.8819 | |
| Formula | C19H17ClN4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO |
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| Chemical Name/SMILES |
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, (6S)- |
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1. Filippakopoulos P, et al. Nature. 2010 Dec 23;468(7327):1067-73.
2. Mertz JA, et al. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16669-74.
3. Dawson MA, et al. Nature. 2011 Oct 2;478(7370):529-33.
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