| Cat. No. |
Product Name |
Information |
| PC-72182 |
GSK046
BET BD2 inhibitor
|
GSK046 (GSK-046, iBET-BD2) is a potent, highly selective inhibitor of BET BD2 with pIC50 of 7.3 (BRD4 BD2), >1000-fold over BRD4 BD1. |
| PC-72181 |
GSK040
BET BD2 inhibitor
|
GSK040 (GSK-040) is a potent, highly selective BET BD2 inhibitor with pIC50 of 8.3 (BRD4 BD2), 5000-fold selectivity over BD1. |
| PC-72180 |
GSK549
BET BD2 inhibitor
|
GSK549 (GSK-549) is a potent, highly selective, BD2 domain-selective BET inhibitor with pIC50 of 7.8 (BRD4 BD2), 1150-fold selectivity over BD1. |
| PC-72179 |
GSK620
BET BD2 inhibitor
|
GSK620 (GSK-620) is a potent, highly selective, BD2 domain-selective BET inhibitor with pIC50 of 7.1 (BRD4 BD2), 220-fold selectivity over BD1. |
| PC-38169 |
NEO2734
CBP/p300-BET inhibitor
|
NEO2734 (NEO-2734, EP31670) is a dual inhibitor of pan-BET and CBP/p300 with Kd values of 2-31 nM. |
| PC-38148 |
Alobresib
BET inhibitor
|
GS-5829 (GS5829, Alobresib) is a novel potent, selective BET inhibitor. |
| PC-38071 |
GSK778
BRD BD1 inhibitor
|
GSK778 is a potent and selective inhibitor of bromodomain (BRD) BD1 with IC50 of 75 nM (BRD2-BD1), 41 nM (BRD3-BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively. |
| PC-38064 |
ODM-207
pan-BET inhibitor
|
ODM-207 (ODM207) is a highly potent, selective and orally active pan-BET inhibitor with potent and broad antiproliferative effects. |
| PC-38040 |
Trotabresib
BET inhibitor
|
Trotabresib (CC90010) is a reversible and orally active BET bromodomain inhibitor, shows significant antiproliferative activity in glioblastoma cells and patient-derived xenograft models as monotherapy and in combination with temozolomide (TMZ). |
| PC-35931 |
Bromotriazine
BET inhibitor
|
Bromotriazine (BTZ) is a covalent probe against bromodomain containing proteins with selectively targeting
non-catalytic, highly conserved amino acid residues.. |
| PC-35848 |
TP-238
|
TP-238 (TP238) is a CECR2/BPTF bromodomains chemical probe with IC50 of 30 nM against CECR2 and 350 nM against BPTF in an alphascreen assay, KD of 10 nM for CECR2 and 120nM for BPTF in ITC assays. |
| PC-35750 |
CN750
BRD4 inhibitor
|
CN750 (CN-750) is novel BRD4 (BD1, 2) inhibitor with IC50 of 44 nM, MV4-11 IC50 of 0.54 uM. |
