SJ018 | BET BD2 inhibitor | Probechem Biochemicals

Chemical Structure : SJ018

SJ018 (SJ-018)

Catalog No.: PC-72186Not For Human Use, Lab Use Only.

SJ018 (SJ-018) is a potent, highly selective BET BD2 inhibitor with KD of 14 nM (BRD2-BD2), 67-fold selectivity over BRD2-BD1.

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Biological Activity

SJ018 (SJ-018) is a potent, highly selective BET BD2 inhibitor with Kd of 14 nM (BRD2-BD2), 67-fold selectivity over BRD2-BD1.
SJ018 is more effective than JQ1 in increasing FRAP in cells, potently inhibits MV4-11 cell growth with GI50 of 2-3 nM (Days3-7).

Physicochemical Properties

M.Wt	471.557
Formula	C28H29N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 4-(((2S,4R)-6-(3-acetamidophenyl)-1-acetyl-2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)amino)benzoate

References

1. P Jake Slavish, et al. Cancer Res. 2020 Sep 1;80(17):3507-3518.

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SJ018 (SJ-018)

Biological Activity

Physicochemical Properties

References

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