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Chemical Structure : SJ018
Catalog No.: PC-72186Not For Human Use, Lab Use Only.
SJ018 (SJ-018) is a potent, highly selective BET BD2 inhibitor with KD of 14 nM (BRD2-BD2), 67-fold selectivity over BRD2-BD1.
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SJ018 (SJ-018) is a potent, highly selective BET BD2 inhibitor with Kd of 14 nM (BRD2-BD2), 67-fold selectivity over BRD2-BD1.
SJ018 is more effective than JQ1 in increasing FRAP in cells, potently inhibits MV4-11 cell growth with GI50 of 2-3 nM (Days3-7).
| M.Wt | 471.557 | |
| Formula | C28H29N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. P Jake Slavish, et al. Cancer Res. 2020 Sep 1;80(17):3507-3518.
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