BRD4 D1 inhibitor 30

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Chemical Structure : BRD4 D1 inhibitor 30

Catalog No.: PC-72261Not For Human Use, Lab Use Only.

BRD4 D1 inhibitor 30 is a high-affinity, BRD4 D1-selective chemical probe with Kd of 18 nM, 500-fold selectivity against BRD2 D1 and BRD4 D2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BRD4 D1 inhibitor 30 is a high-affinity, BRD4 D1-selective chemical probe with Kd of 18 nM, 500-fold selectivity against BRD2 D1 and BRD4 D2.
BRD4 D1 inhibitor 30 down regulated inflammation, IL-8 and chemokine in cell based assays, but was unable to reduce c-Myc expression at low concentration in multiple myeloma cells.

Physicochemical Properties

M.Wt	578.684
Formula	C32H37F3N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(3-(5-(2-(5-isopropyl-2-methylphenoxy)pyrimidin-4-yl)-4-(4-(trifluoromethyl)phenyl)-1H-imidazol-1-yl)pyrrolidin-1-yl)-N,N-dimethylethan-1-amine

References

1. Huarui Cui, et al. J Med Chem. 2022 Feb 10;65(3):2342-2360.

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