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Chemical Structure : BRD8 inhibitor DN02
CAS No.: 3055009-00-9
Catalog No.: PC-72321Not For Human Use, Lab Use Only.
BRD8 inhibitor DN02 is a first-in-class selective and cellularly active probe for NuA4 factor BRD8 (BD1) with AlphaScreen IC50 of 48 nM, and Kd of 34 nM.
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| 5 mg | $388 | In stock | |
| 10 mg | $578 | In stock | |
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BRD8 inhibitor DN02 is a first-in-class selective and cellularly active probe for NuA4 factor BRD8 (BD1) with AlphaScreen IC50 of 48 nM, and Kd of 34 nM.
BRD8 inhibitor DN02 displays IC50 of 0.64 uM in-cell engagement within BRET displacement assays.
BRD8 inhibitor DN02 shows no affinity for BRD8 (BD2), CBP, and p300 (IC50>10 uM).
| M.Wt | 397.450 | |
| Formula | C22H24FN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(4-((3-aminoazetidin-1-yl)methyl)-2,6-dimethoxyphenyl)-7-fluoro-2-methylisoquinolin-1(2H)-one |
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1. David Remillard, et al. ACS Chem Biol. 2021 Nov 19;16(11):2185-2192.
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