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Chemical Structure : BY27
Catalog No.: PC-72188Not For Human Use, Lab Use Only.
BY27 (BD2 inhibitor BY27) is a potent, highly selective BET BD2 inhibitor with Ki of 8.9/8.2/14.2 nM for BRD2/3/4-BD2 respectively.
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BY27 (BD2 inhibitor BY27) is a potent, highly selective BET BD2 inhibitor with Ki of 8.9/8.2/14.2 nM for BRD2/3/4-BD2 respectively.
BY27 displays 38-fold selectivity for BRD2-BD2 over BRD2-BD1.
BY27 showed good antitumor activity in the MV4-11 xenograft model with an improved in vivo tolerance in mice compared with I-BET762.
| M.Wt | 404.902 | |
| Formula | C22H21ClN6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Deheng Chen, et al. Eur J Med Chem. 2019 Nov 15;182:111633.
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