BY27 | BET BD2 inhibitor | Probechem Biochemicals

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Chemical Structure : BY27

BY27 (BD2 inhibitor BY27)

Catalog No.: PC-72188Not For Human Use, Lab Use Only.

BY27 (BD2 inhibitor BY27) is a potent, highly selective BET BD2 inhibitor with Ki of 8.9/8.2/14.2 nM for BRD2/3/4-BD2 respectively.

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Biological Activity

BY27 (BD2 inhibitor BY27) is a potent, highly selective BET BD2 inhibitor with Ki of 8.9/8.2/14.2 nM for BRD2/3/4-BD2 respectively.
BY27 displays 38-fold selectivity for BRD2-BD2 over BRD2-BD1.
BY27 showed good antitumor activity in the MV4-11 xenograft model with an improved in vivo tolerance in mice compared with I-BET762.

Physicochemical Properties

M.Wt	404.902
Formula	C22H21ClN6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(4-Chlorophenyl)-1-methyl-8-(1-methyl-1H-pyrazol4-yl)-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a]azepin-6- amine

References

1. Deheng Chen, et al. Eur J Med Chem. 2019 Nov 15;182:111633.

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BY27 (BD2 inhibitor BY27)

Biological Activity

Physicochemical Properties

References

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