Cat. No. |
Product Name |
Information |
PC-20463 |
BI 1702135
SMARCA2 binder
|
BI 1702135 (Compound 4) is a potent SMARCA2 binder for targeted protein degradation (PROTAC) design as BI 1810284 (ACBI2, Cat. PC-20464). |
PC-20161 |
I-BET282E
BET inhibitor
|
I-BET282E (I-BET282 mesylate) is the mesylate salt of I-BET282, I-BET282 is a potent and selective pan-inhibitor of bromodomain and extra terminal (BET) proteins. |
PC-49860 |
FT-6876
CBP/p300 inhibitor
|
FT-6876 (FT 6876) is a potent, selective, orally active CBP/p300 bromodomains inhibitor with IC50 of 5/2 nM, respectively, >500-fold selectivity over BRD4 (IC50=2,320 nM) and other bromodomains. |
PC-49526 |
BAZ1A inhibitor Cpd2
BAZ1A inhibitor
|
BAZ1A inhibitor Cpd2 is a small molecule BAZ1A bromodomain inhibitor with KD value of 0.52 uM, displays good anti-viability activity against cancer cell lines expressing a high level of BAZ1A. |
PC-49366 |
iBRD4-BD1
BRD4-BD1 inhibitor
|
iBRD4-BD1 is a potent, selective inhibitor of the first BRD4 bromodomain with IC50 of 12 nM, shows 23- to 6200-fold intra-BET selectivity. |
PC-49300 |
TDI-11055
ENL YEATS Domain inhibitor
|
TDI-11055 (TDI 11055) is a potent, selective and orally bioavailable inhibitor of the acyl-lysine reader ENL/AF9 YEATS domain with IC50 of 0.05 and 0.07 uM, respectively. |
PC-49210 |
GNE-064
BRM/BRG1 inhibitor
|
GNE-064 (GNE064) is a potent, selective, and orally bioavailable inhibitor of the bromodomains of SMARCA2 (BRM), SMARCA4 (BRG1) and PBRM1 (polybromo-1) bromodomain 5 (PBRM1(5)) with IC50 of 10 nM, 16 nM and 18 nM, respectively. |
PC-49079 |
RVX-208
BET BD2 inhibitor
|
Apabetalone (RVX-208) is a potent, selective inhibitor of second BET bromodomains (BD2) with IC50 of 0.51 uM, 170-fold selectivity over BD1 (IC50=87 uM). |
PC-38776 |
CDD-956
BET BD1 inhibitor
|
CDD-956 is a highly potent, selective BET bromodomain 1 (BET BD1) inhibitor with IC50 of 2.1 and 4.4 nM for BRDT-BD1 and BRD4-BD1 respectively, with high selectivity (>500-fold) over BET BD2 proteins. |
PC-38775 |
CDD-787
BET BD1 inhibitor
|
CDD-787 is a highly potent, selective BET bromodomain 1 (BET BD1) inhibitor with IC50 of 2.1 and 3.3 nM for BRDT-BD1 and BRD4-BD1, respectively, with high selectivity (>3,000-fold) over BET BD2 proteins. |
PC-73385 |
SRX3305
BTK/PI3K/BRD4 inhibitor
|
SRX3305 is a potent, triple BTK/PI3K/BRD4 inhibitor with IC50 of 6.5 nM, 15 nM, and 4 nM toward BTK, PI3Kɑ and PI3Kδ respectively, inhibits BRD4 BD1 and BD2 with IC50 of 77 and 95 nM. |
PC-73384 |
SRX3262
BTK/PI3K/BRD4 inhibitor
|
SRX3262 (SRX 3262, SRX 3262) is a potent, triple action BTK, PI3K and BRD4 inhibitor with potency against BTK (IC50=35 nM), PI3Kδ (IC50=16 nM), PI3Kα (IC50=64 nM), and both bromodomains of BRD4 (IC50 BD1=228 nM, IC50 BD2=348 nM). |