ipAE1

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Chemical Structure : ipAE1

Catalog No.: PC-27999Not For Human Use, Lab Use Only.

ipAE1 is a highly potent, BD2-selective, covalent inhibitor of bromodomain and extra-terminal (BET) proteins with Kd of 0.092 nM for BRD4(2), has >1900-fold selectivity over BRD4(1), shows potent antiproliferative activity in MV4-11 cells with IC50 of 1.5 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ipAE1 is a highly potent, BD2-selective, covalent inhibitor of bromodomain and extra-terminal (BET) proteins with Kd of 0.092 nM for BRD4(2), has >1900-fold selectivity over BRD4(1), shows potent antiproliferative activity in MV4-11 cells with IC50 of 1.5 nM.

Physicochemical Properties

M.Wt	559.66
Formula	C32H37N3O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-(2,6-dimethyl-4-((2-methyloxiran-2-yl)methoxy)phenoxy)-5-(2-hydroxypropan-2-yl)phenyl)-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide

References

1. Kang J, et al. Angew Chem Int Ed Engl. 2026 Sep 4:e1224416.

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ipAE1

Biological Activity

Physicochemical Properties

References

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