Chemical Structure : KB-0118
CAS No.:
2648377-08-4
KB-0118
(KB0118)
Catalog No.: PC-24237Not For Human Use, Lab Use Only.
KB-0118 is a selective BET bromodomain inhibitor with Kd of 36.7 uM for BRD2 BD1 and 47.4 uM for BRD4 BD1, shows immunomodulatory effects in inflammatory bowel disease (IBD).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
KB-0118 is a selective BET bromodomain inhibitor with Kd of 36.7 uM for BRD2 BD1 and 47.4 uM for BRD4 BD1, shows immunomodulatory effects in inflammatory bowel disease (IBD).
KB-0118 demonstrates selective binding to BRD2 and BRD4 over BRD3 in TR-FRET assays.
KB-0118 effectively inhibited pro-inflammatory cytokines, including TNF, IL-1β, and IL-23a, and selectively suppressed Th17 cell differentiation, a critical driver of IBD pathology.
KB-0118 significantly reduced disease severity, preserved colon structure, and lowered IL-17 expression in both DSS-induced and T cell-mediated colitis models.
Physicochemical Properties
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M.Wt
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309.28
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Formula
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C17H11NO5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3,5,7-trihydroxy-2-(1H-indol-6-yl)-4H-chromen-4-one
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References
1. Jeong YJ, et al. Biomed Pharmacother. 2025 Mar 14;185:117933.
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