BI 7271 |CAS:1883429-34-2 Probechem Biochemicals

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Chemical Structure : BI 7271

BI 7271 (BI7271, BI-7271)

Catalog No.: PC-62272Not For Human Use, Lab Use Only.

BI 7271 is a highly selective bromodomains of BRD9 and BRD7 inhibitor with IC50<50 nM for BRD9.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BI 7271 is a highly selective bromodomains of BRD9 and BRD7 inhibitor with IC50<50 nM for BRD9.
BI 7271 displays >1,000 fold selectivity over the bromodomains of BRD4.
BI 7271 suppresses the proliferation of AML cells.

Physicochemical Properties

M.Wt	352.434
Formula	C21H24N2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methylisoquinolin-1-one

References

1. Hohmann AF, et al. Nat Chem Biol. 2016 Sep;12(9):672-9.

2. Pérez-Salvia M, et al. Epigenetics. 2017 May 4;12(5):323-339.

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BI 7271 (BI7271, BI-7271)

Biological Activity

Physicochemical Properties

References

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