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BI 7271

Chemical Structure : BI 7271

CAS No.: 1883429-34-2

BI 7271 (BI7271, BI-7271)

Catalog No.: PC-62272Not For Human Use, Lab Use Only.

BI 7271 is a highly selective bromodomains of BRD9 and BRD7 inhibitor with IC50<50 nM for BRD9.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BI 7271 is a highly selective bromodomains of BRD9 and BRD7 inhibitor with IC50<50 nM for BRD9.
    BI 7271 displays >1,000 fold selectivity over the bromodomains of BRD4.
    BI 7271 suppresses the proliferation of AML cells.

    Physicochemical Properties

    M.Wt 352.434
    Formula C21H24N2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methylisoquinolin-1-one

    References

    1. Hohmann AF, et al. Nat Chem Biol. 2016 Sep;12(9):672-9.

    2. Pérez-Salvia M, et al. Epigenetics. 2017 May 4;12(5):323-339.

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