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Chemical Structure : TP-472
CAS No.: 2079895-62-6
Catalog No.: PC-62273Not For Human Use, Lab Use Only.
TP-472 is a novel BRD9/7 chemical probe that has excellent potency (BRD9 KD=33nM, BRD7 KD=340 nM by ITC), >30 fold selectivity over all other bromodomain family members except BRD7 and is cell active (EC50 320 nM in a BRD9 NanoBRET assay).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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TP-472 is a novel BRD9/7 chemical probe that has excellent potency (BRD9 KD=33nM, BRD7 KD=340 nM by ITC), >30 fold selectivity over all other bromodomain family members except BRD7 and is cell active (EC50 320 nM in a BRD9 NanoBRET assay).
TP-472 has a good PK profile and is suitable for in vivo applications.
| M.Wt | 333.391 | |
| Formula | C20H19N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-(6-acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide |
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1. Pérez-Salvia M, et al. Epigenetics. 2017 May 4;12(5):323-339.
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