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Chemical Structure : OF-1
CAS No.: 919973-83-4
Catalog No.: PC-62276Not For Human Use, Lab Use Only.
OF-1 is a potent bromodomain inhibitor that inhibits BRPF1B/2/3 bromodomains with Kd of 0.1/0.5/2.4 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $448 | In stock | |
| 100 mg | $658 | In stock |
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OF-1 is a potent bromodomain inhibitor that inhibits BRPF1B/2/3 bromodomains with Kd of 0.1/0.5/2.4 uM; displays good selectivity against other bromodomains, 39-fold selectivity over closest off-target BRD4.
| M.Wt | 440.312 | |
| Formula | C17H18BrN3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methylbenzenesulfonamide |
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1. Demont EH, et al. ACS Med Chem Lett. 2014 Sep 10;5(11):1190-5.
2. Pérez-Salvia M, et al. Epigenetics. 2017 May 4;12(5):323-339.
3. Meier JC, et al. ACS Chem Biol. 2017 Oct 20;12(10):2619-2630.
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