OF-1 |CAS:919973-83-4 Probechem Biochemicals

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Chemical Structure : OF-1

CAS No.: 919973-83-4

OF-1

Catalog No.: PC-62276Not For Human Use, Lab Use Only.

OF-1 is a potent bromodomain inhibitor that inhibits BRPF1B/2/3 bromodomains with Kd of 0.1/0.5/2.4 uM.

Packing	Price	Stock
5 mg	$88	In stock
25 mg	$258	In stock
50 mg	$448	In stock
100 mg	$658	In stock

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

OF-1 is a potent bromodomain inhibitor that inhibits BRPF1B/2/3 bromodomains with Kd of 0.1/0.5/2.4 uM; displays good selectivity against other bromodomains, 39-fold selectivity over closest off-target BRD4.

Physicochemical Properties

M.Wt	440.312
Formula	C17H18BrN3O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methylbenzenesulfonamide

References

1. Demont EH, et al. ACS Med Chem Lett. 2014 Sep 10;5(11):1190-5.

2. Pérez-Salvia M, et al. Epigenetics. 2017 May 4;12(5):323-339.

3. Meier JC, et al. ACS Chem Biol. 2017 Oct 20;12(10):2619-2630.

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OF-1

Biological Activity

Physicochemical Properties

References

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