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BRD-IN-26

Chemical Structure : BRD-IN-26

CAS No.: 1915012-19-9

BRD-IN-26

Catalog No.: PC-62277Not For Human Use, Lab Use Only.

BRD-IN-26 is a potent bromodomain inhibitor that binds the fifth bromodomain of PB1 (PB1(5)) with a KD of 124 nM, SMARCA2B and SMARCA4 with KD values of 262 and 417 nM, respectively.

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    Biological Activity

    BRD-IN-26 is a potent bromodomain inhibitor that binds the fifth bromodomain of PB1 (PB1(5)) with a KD of 124 nM, SMARCA2B and SMARCA4 with KD values of 262 and 417 nM, respectively.
    BRD-IN-26 displays excellent selectivity over other bromodomains.

    Physicochemical Properties

    M.Wt 330.816
    Formula C17H19ClN4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (E)-6-chloro-3-((4-methylpiperazin-1-yl)methylene)-2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one

    References

    1. Sutherell CL, et al. J Med Chem. 2016 May 26;59(10):5095-101.

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