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Chemical Structure : SDU-071
Catalog No.: PC-22204Not For Human Use, Lab Use Only.
SDU-071 is a potent small molecule BRD4-p53 PPI inhibitor with IC50 of 2.7 uM, reduces the expression of BRD4-regulated genes, such as c-Myc and Mucin 5AC, and induces cell cycle arrest and apoptosis.
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SDU-071 is a potent small molecule BRD4-p53 PPI inhibitor with IC50 of 2.7 uM, reduces the expression of BRD4-regulated genes, such as c-Myc and Mucin 5AC, and induces cell cycle arrest and apoptosis.
SDU-071 potentially disrupts BRD4 interaction with p53 through a contact interface between pPDID and p53 REG.
SDU-071 interacts with BRD4 to disrupt its interaction with p53.
SDU-071 displays potent antiproliferation of MDA-MB-231 cells with IC50 of 10.5 μM (72 h), inhibits MDA-MB-231 cell proliferation, migration, and invasion.
SDU-071 alters cell cycle progression and induces apoptosis in MDA-MB-231 cells.
SDU-071 perturbs BRD4-regulated pathways and downregulates c-Myc and Mucin 5AC expression.
SDU-071 (50 mg/kg) inhibits tumor growth in an MDA-MB-231 orthotopic xenograft mammary tumor model, without causing serious side effects.
| M.Wt | 435.53 | |
| Formula | C28H25N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shumei Wang, et al. ACS Pharmacol Transl Sci. 2024 Mar 12;7(4):1178-1190.
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