Chemical Structure : SDU-071
CAS No.:
SDU-071
(SDU071)
Catalog No.: PC-22204Not For Human Use, Lab Use Only.
SDU-071 is a potent small molecule BRD4-p53 PPI inhibitor with IC50 of 2.7 uM, reduces the expression of BRD4-regulated genes, such as c-Myc and Mucin 5AC, and induces cell cycle arrest and apoptosis.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SDU-071 is a potent small molecule BRD4-p53 PPI inhibitor with IC50 of 2.7 uM, reduces the expression of BRD4-regulated genes, such as c-Myc and Mucin 5AC, and induces cell cycle arrest and apoptosis.
SDU-071 potentially disrupts BRD4 interaction with p53 through a contact interface between pPDID and p53 REG.
SDU-071 interacts with BRD4 to disrupt its interaction with p53.
SDU-071 displays potent antiproliferation of MDA-MB-231 cells with IC50 of 10.5 μM (72 h), inhibits MDA-MB-231 cell proliferation, migration, and invasion.
SDU-071 alters cell cycle progression and induces apoptosis in MDA-MB-231 cells.
SDU-071 perturbs BRD4-regulated pathways and downregulates c-Myc and Mucin 5AC expression.
SDU-071 (50 mg/kg) inhibits tumor growth in an MDA-MB-231 orthotopic xenograft mammary tumor model, without causing serious side effects.
Physicochemical Properties
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M.Wt
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435.53
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Formula
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C28H25N3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(4-methoxyphenyl)-2-(((4-methoxyphenyl)amino)methyl)benzo[h]quinolin-4-amine
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References
1. Shumei Wang, et al. ACS Pharmacol Transl Sci. 2024 Mar 12;7(4):1178-1190.
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