I-BET469

Chemical Structure : I-BET469

Catalog No.: PC-22528Not For Human Use, Lab Use Only.

I-BET469 is a potent, selective pan-BET bromodomain inhibitor with pIC50 of 7.9 for BRD4 BD1, >5000-fold selective over BAZ2A.

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Biological Activity

I-BET469 is a potent, selective pan-BET bromodomain inhibitor with pIC50 of 7.9 for BRD4 BD1, >5000-fold selective over BAZ2A.
I-BET469 inhibits human whole blood MCP-1 with an pIC50 value of 7.6, inhibits LPS-stimulated hWB IL-6 with pIC50 of 7.7.

Physicochemical Properties

M.Wt	426.52
Formula	C23H30N4O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(1-(1,3-Dimethoxypropan-2-yl)-5-morpholino-1H-benzo[d]imidazol-2-yl)-1,3-dimethylpyridin-2(1H)-one

References

1. Christopher R Wellaway, et al. J Med Chem. 2020 Jan 23;63(2):714-746.

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I-BET469

Biological Activity

Physicochemical Properties

References

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