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Chemical Structure : BBC0403
Catalog No.: PC-22158Not For Human Use, Lab Use Only.
BBC0403 (BBC-0403) is a specific BRD2 inhibitor with binding Kd of 41.4 uM and 7.6 uM for BRD2 (BD1) and BRD2 (BD2), inhibits the NF-κB and MAPK signalling pathways and the progression of osteoarthritis pathogenesis.
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BBC0403 (BBC-0403) is a specific BRD2 inhibitor with binding Kd of 41.4 uM and 7.6 uM for BRD2 (BD1) and BRD2 (BD2), inhibits the NF-κB and MAPK signalling pathways and the progression of osteoarthritis pathogenesis.
BBC0403 displays no affinity for BRD3 (BD1), BRD4 (BD1) and BRD4 (BD2), (Kd>1000 uM).
BBC0403 decreases catabolic factors in osteoarthritis (OA) mimic condition and inhibited extracellular matrix (ECM) degradation.
BBC0403 decreases IL-1β-induced expression of catabolic factors in mouse primary chondrocytes.
BBC0403 (5 and 10 ug/kg, i.a. injection, once a week for 7 weeks) inhibits DMM surgery-induced expression of catabolic factors, preventing cartilage degradation in DMM-induced OA model.
The anti-OA effect of BBC0403 is associated with inhibiting NF-κB and MAPK signalling activated by IL-1β.
| M.Wt | 382.42 | |
| Formula | C21H22N2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hyemi Lee, et al. Br J Pharmacol. 2024 Apr 10. doi: 10.1111/bph.16359.
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