Chemical Structure : BBC0403
CAS No.:
2644662-83-7
BBC0403
(BBC-0403)
Catalog No.: PC-22158Not For Human Use, Lab Use Only.
BBC0403 (BBC-0403) is a specific BRD2 inhibitor with binding Kd of 41.4 uM and 7.6 uM for BRD2 (BD1) and BRD2 (BD2), inhibits the NF-κB and MAPK signalling pathways and the progression of osteoarthritis pathogenesis.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BBC0403 (BBC-0403) is a specific BRD2 inhibitor with binding Kd of 41.4 uM and 7.6 uM for BRD2 (BD1) and BRD2 (BD2), inhibits the NF-κB and MAPK signalling pathways and the progression of osteoarthritis pathogenesis.
BBC0403 displays no affinity for BRD3 (BD1), BRD4 (BD1) and BRD4 (BD2), (Kd>1000 uM).
BBC0403 decreases catabolic factors in osteoarthritis (OA) mimic condition and inhibited extracellular matrix (ECM) degradation.
BBC0403 decreases IL-1β-induced expression of catabolic factors in mouse primary chondrocytes.
BBC0403 (5 and 10 ug/kg, i.a. injection, once a week for 7 weeks) inhibits DMM surgery-induced expression of catabolic factors, preventing cartilage degradation in DMM-induced OA model.
The anti-OA effect of BBC0403 is associated with inhibiting NF-κB and MAPK signalling activated by IL-1β.
Physicochemical Properties
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M.Wt
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382.42
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Formula
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C21H22N2O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(3,5-dimethyl-4-(oxetan-3-yloxy)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one
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References
1. Hyemi Lee, et al. Br J Pharmacol. 2024 Apr 10. doi: 10.1111/bph.16359.
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