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Chemical Structure : LT052
Catalog No.: PC-21331Not For Human Use, Lab Use Only.
LT052 is a potent, selective BET BD1 bromodomain inhibitor with IC50 of 88 nM, 138-fold selectivity for BRD4 BD1 over BRD4 BD2.
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LT052 is a potent, selective BET BD1 bromodomain inhibitor with IC50 of 88 nM, 138-fold selectivity for BRD4 BD1 over BRD4 BD2.
LT052 mediates BRD4/NF-κB/NLRP3 signaling inflammatory pathways with comparable protein expression and significantly improves symptoms of gout arthritis in a rat model.
| M.Wt | 449.49 | |
| Formula | C22H19N5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fei Jiang, et al. J Med Chem. 2019 Dec 26;62(24):11080-11107.
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