LT052 | BET BD1 inhibitor | Probechem Biochemicals

Chemical Structure : LT052

LT052 (LT-052, LT 052)

Catalog No.: PC-21331Not For Human Use, Lab Use Only.

LT052 is a potent, selective BET BD1 bromodomain inhibitor with IC50 of 88 nM, 138-fold selectivity for BRD4 BD1 over BRD4 BD2.

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Biological Activity

LT052 is a potent, selective BET BD1 bromodomain inhibitor with IC50 of 88 nM, 138-fold selectivity for BRD4 BD1 over BRD4 BD2.
LT052 mediates BRD4/NF-κB/NLRP3 signaling inflammatory pathways with comparable protein expression and significantly improves symptoms of gout arthritis in a rat model.

Physicochemical Properties

M.Wt	449.49
Formula	C22H19N5O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzenesulfonamide, N-[1,2-dihydro-1-methyl-4-(4-methyl-1H-imidazol-1-yl)-2-oxopyrrolo[4,3,2-de]quinolin-6-yl]-2-methoxy-

References

1. Fei Jiang, et al. J Med Chem. 2019 Dec 26;62(24):11080-11107.

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LT052 (LT-052, LT 052)

Biological Activity

Physicochemical Properties

References

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