Chemical Structure : DDO-8926
CAS No.:
DDO-8926
(DDO 8926)
Catalog No.: PC-20948Not For Human Use, Lab Use Only.
DDO-8926 is a potent selective inhibitor of bromodomain and extra-terminal (BET) proteins with Ki values of 15 nM (BRD4 BD1) and 9.5 nM (BRD4 BD2).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DDO-8926 is a potent selective inhibitor of bromodomain and extra-terminal (BET) proteins with Ki values of 15 nM (BRD4 BD1) and 9.5 nM (BRD4 BD2).
DDO-8926 showed excellent selectivity over the non-BET bromodomains at 1 uM by the BROMOscan (Eurofins DiscoverX).
DDO-8926 (30 mg/kg, ip) attenuates NP hypersensitivity, regulates genes involved in the generation and transfer of action potentials and inflammatory response.
DDO-8926 reduces microglial and neuronal activation in the spinal cord after SNI and has no effect on astrocytes, alleviates inflammation and affects the expression of ion channels and the Na+/K+ ATPase pump in the spinal cord at 15 dpo after SNI.
Physicochemical Properties
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M.Wt
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428.49
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Formula
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C20H21FN6O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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CCS(=O)(NC1=CC(C2=C(C)N(C)N=C2C)=C(F)C(C3=C4C(N=CN4)=NC=C3)=C1)=O
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References
1. Xuetao Chen, et al. J Med Chem. 2023 Jul 13;66(13):8725-8744.
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