Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : DDO-8926
Catalog No.: PC-20948Not For Human Use, Lab Use Only.
DDO-8926 is a potent selective inhibitor of bromodomain and extra-terminal (BET) proteins with Ki values of 15 nM (BRD4 BD1) and 9.5 nM (BRD4 BD2).
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
DDO-8926 is a potent selective inhibitor of bromodomain and extra-terminal (BET) proteins with Ki values of 15 nM (BRD4 BD1) and 9.5 nM (BRD4 BD2).
DDO-8926 showed excellent selectivity over the non-BET bromodomains at 1 uM by the BROMOscan (Eurofins DiscoverX).
DDO-8926 (30 mg/kg, ip) attenuates NP hypersensitivity, regulates genes involved in the generation and transfer of action potentials and inflammatory response.
DDO-8926 reduces microglial and neuronal activation in the spinal cord after SNI and has no effect on astrocytes, alleviates inflammation and affects the expression of ion channels and the Na+/K+ ATPase pump in the spinal cord at 15 dpo after SNI.
| M.Wt | 428.49 | |
| Formula | C20H21FN6O2S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Xuetao Chen, et al. J Med Chem. 2023 Jul 13;66(13):8725-8744.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
