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IV-255

Chemical Structure : IV-255

CAS No.:

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IV-255 (IV 255)

Catalog No.: PC-21072Not For Human Use, Lab Use Only.

IV-255 is a next-generation selective inhibitor of BRG1 bromodomain, inhibits SWI/SNF complex and enhances DNA damage and cell death in glioblastoma.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

IV-255 is a next-generation selective inhibitor of BRG1 bromodomain, inhibits SWI/SNF complex and enhances DNA damage and cell death in glioblastoma.
IV-255 only enhances TMZ-induced death in GBM cells that express the BRG1 subunit, has no such effect in BRG1KO GBM cells.
IV-255 increases the amount of DNA-damage induced by TMZ and bleomycin.
IV-255 (20 uM, 24h) inhibits cell invasion and IFN-induced gene expression in MT330 and LN229 GBM cells.
IV-255 reduces the IFN-induced expression of CXCl11, increases IFN-induced expression of STAT1, IRF1 and IRF7 in GBM cell lines.

Physicochemical Properties

M.Wt 359.38
Formula C19H19F2N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(N1[C@@](C2)([H])CN(C3=CC=C(OC)C=C3)[C@@]2([H])C1)NC4=CC=C(F)C(F)=C4

References

1. Chuanhe Yang, et al. J Cell Mol Med. 2023 Aug 18.

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