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Chemical Structure : PFI-3
CAS No.: 1819363-80-8
Catalog No.: PC-62279Not For Human Use, Lab Use Only.
PFI-3 (PF-06687252) is a potent and cell active BRG/PB1 bromodomains inhibitor with Kd of 54-97 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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PFI-3 (PF-06687252) is a potent and cell active BRG/PB1 bromodomains inhibitor with Kd of 54-97 nM.
PFI-3 (PF-06687252) shows high selectivity over other bromodomains.
Exposure of embryonic stem cells to PFI-3 led to deprivation of stemness and deregulated lineage specification。
PFI-3 (PF-06687252) markedly enhances the differentiation of trophoblast stem cells。
PFI-3 (PF-06687252) attenuates adipocyte differentiation and dramatically decreases lipid accumulation。
PFI-3 (PF-06687252) a first in class chemical probe for Family VIII bromodomains.
| M.Wt | 321.38 | |
| Formula | C19H19N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-1-(2-hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one |
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1. Fedorov O, et al. Sci Adv. 2015 Nov 13;1(10):e1500723.
2. Vangamudi B, et al. Cancer Res. 2015 Sep 15;75(18):3865-78.
3. Gerstenberger BS, et al. J Med Chem. 2016 May 26;59(10):4800-11.
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