PFI-3 | BRG/PB1 inhibitor | Probechem Biochemicals

Chemical Structure : PFI-3

CAS No.: 1819363-80-8

PFI-3 (PF-6687252, PF-06687252)

Catalog No.: PC-62279Not For Human Use, Lab Use Only.

PFI-3 (PF-06687252) is a potent and cell active BRG/PB1 bromodomains inhibitor with Kd of 54-97 nM.

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10 mg	$128	In stock
25 mg	$218	In stock
50 mg	$358	In stock
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Biological Activity

PFI-3 (PF-06687252) is a potent and cell active BRG/PB1 bromodomains inhibitor with Kd of 54-97 nM.
PFI-3 (PF-06687252) shows high selectivity over other bromodomains.
Exposure of embryonic stem cells to PFI-3 led to deprivation of stemness and deregulated lineage specification.
PFI-3 (PF-06687252) markedly enhances the differentiation of trophoblast stem cells.
PFI-3 (PF-06687252) attenuates adipocyte differentiation and dramatically decreases lipid accumulation.
PFI-3 (PF-06687252) a first in class chemical probe for Family VIII bromodomains.

Physicochemical Properties

M.Wt	321.38
Formula	C19H19N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-1-(2-hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one

References

1. Fedorov O, et al. Sci Adv. 2015 Nov 13;1(10):e1500723.

2. Vangamudi B, et al. Cancer Res. 2015 Sep 15;75(18):3865-78.

3. Gerstenberger BS, et al. J Med Chem. 2016 May 26;59(10):4800-11.

PFI-3 (PF-6687252, PF-06687252)

Biological Activity

Physicochemical Properties

References

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