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LP99

Chemical Structure : LP99

CAS No.: 1808951-93-0

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LP99 (BRD7/9 inhibitor LP99)

Catalog No.: PC-62299Not For Human Use, Lab Use Only.

LP99 is the first potent and selective BRD7/9 bromodomain inhibitor with Kd of 99 nM for BRD9.

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5 mg $128 In stock
10 mg $188 In stock
25 mg $328 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LP99 is the first potent and selective BRD7/9 bromodomain inhibitor with Kd of 99 nM for BRD9.
LP99 inhibits IL‐6 secretion from THP‐1 cells in a dose‐dependent manner.
LP99 decreases BRET for both BRD7 and BRD9 in both the H3.3 and H4 systems in a dose‐dependent manner, with cellular IC50 values in the low micromolar range for both histones.

Physicochemical Properties

M.Wt 516.05
Formula C26H30ClN3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-1-propanesulfonamide

References

1. Clark PG, et al. Angew Chem Weinheim Bergstr Ger. 2015 May 18;127(21):6315-6319.

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