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FT-1101

Chemical Structure : FT-1101

CAS No.: 1776060-36-6

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FT-1101 (FT1101, FT 1101)

Catalog No.: PC-62284Not For Human Use, Lab Use Only.

FT-1101 is a potent pan-BET bromodomain inhibitor that displays equipotent inhibition for BRD2, BRD3, BRD4, and BRDT with Kd < 20 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    FT-1101 is a potent pan-BET bromodomain inhibitor that displays equipotent inhibition for BRD2, BRD3, BRD4, and BRDT with Kd < 20 nM.
    FT-1101  displays potent anti-proliferative activity across a broad panel of human leukemia, lymphoma, and multiple myeloma cell lines, with 66 out of 123 cell lines having IC50 < 500 nM (IC50=40 nM, MV-4-11 cells).
    FT-1101  down-regulates MYC gene and protein expression.
    FT-1101  significantly tumor growth in the MV-4-11 xenograft model; orally bioavtive.

    Physicochemical Properties

    M.Wt 434.58
    Formula C26H34N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    [(2S)-5-(Cyclobutyloxy)-3,4-dihydro-2-methyl-6-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-1(2H)-quinolinyl]cyclopropylmethanone

    References

    1. David S Millan, et al. Blood. 2015 126:1367.

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