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BAY299

Chemical Structure : BAY299

CAS No.: 2080306-23-4

BAY299 (BAY-299, BAY 299)

Catalog No.: PC-62287Not For Human Use, Lab Use Only.

BAY 299 is a potent and selective inhibitor of the bromodomain and PHD finger-containing (BRPF) family protein BRD1 and the second bromodomain of TAF1 with IC50 of 6 nM and 13 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BAY299 (BAY-299) is a potent and selective inhibitor of the bromodomain and PHD finger-containing (BRPF) family protein BRD1 and the second bromodomain of TAF1 with IC50 of 6 nM and 13 nM, respectively.
BAY299 dispalys >30-fold selective over BRPF1, BRPF3, BRD9, and ATAD2 and is >300-fold selective over BRD4.

Physicochemical Properties

M.Wt 429.476
Formula C25H23N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(2,3-dihydro-1,3,6-trimethyl-2-oxo-1H-benzimidazol-5-yl)-6-(3-hydroxypropyl)-1H-benz[de]isoquinoline-1,3(2H)-dione

References

1. Pérez-Salvia M, et al. Epigenetics. 2017 May 4;12(5):323-339.

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