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Chemical Structure : Mivebresib
CAS No.: 1445993-26-9
Catalog No.: PC-42029Not For Human Use, Lab Use Only.
Mivebresib (ABBV-075) is a potent and orally available BET bromodomain inhibitor with Ki of 1.0, 12.2, 1.5, and 2.2 nM for BRD2, BRD3, BRD4 and BRDT, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $478 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Mivebresib (ABBV-075) is a potent and orally available BET bromodomain inhibitor with Ki of 1.0, 12.2, 1.5, and 2.2 nM for BRD2, BRD3, BRD4 and BRDT, respectively.
Mivebresib (ABBV-075) displays 54-fold selectivity over EP300, has potential weak activity against SMARCA4 (70% inhibition at 1 uM), Kd >1 uM for 18 other bromodomains.
Mivebresib (ABBV-075) exhibits inhibition of c-Myc expression and displacing BRD4 from the Myc promoter.
Mivebresib (ABBV-075) dose-dependently inhibits IL-6 concentration in a murine model of LPS-induced endotoxic shock, shows vivo antitumor efficacy in a Kasumi-1 AML mouse xenograft model.
| M.Wt | 459.4658 | |
| Formula | C22H19F2N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 37 mg/mL |
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| Chemical Name/SMILES |
Ethanesulfonamide, N-[4-(2,4-difluorophenoxy)-3-(6,7-dihydro-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]- |
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1. McDaniel KF, et al. J Med Chem. 2017 Oct 26;60(20):8369-8384.
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