FRC-303 | CHD1 inhibitor | Probechem Biochemicals

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Chemical Structure : FRC-303

FRC-303 (CHD1 inhibitor 2s)

Catalog No.: PC-26723Not For Human Use, Lab Use Only.

FRC-303 (CHD1 inhibitor 2s) is a selective small molecule CHD1 chromodomain inhibitor, targets the H3K4me3 binding site of tandem chromodomain (tCD) with Kd of 0.14 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

FRC-303 (CHD1 inhibitor 2s) is a selective small molecule CHD1 chromodomain inhibitor, targets the H3K4me3 binding site of tandem chromodomain (tCD) with Kd of 0.14 uM.
CHD1 inhibitor 2s engage endogenous CHD1 in cell lysates or the exogenous CHD1 tCD in cells.
CHD1 inhibitor 2s displays selectivity against a panel of methyl-lysine readers and epigenetic enzymes as well as impairment of PCa cell viability.

Physicochemical Properties

M.Wt	704.92
Formula	C41H52N8O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-Benzylpiperidine-4-yl)-7-ethoxy-2-(4-((4-((1-(2-methoxyethyl)-1H-1,2,3-triazol-4-yl)methoxy)benzyl)-amino)-piperidine-1-yl)quinoline-4-amine

References

1. Greschik H, et al. J Med Chem. 2026 May 5. doi: 10.1021/acs.jmedchem.5c03690.

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FRC-303 (CHD1 inhibitor 2s)

Biological Activity

Physicochemical Properties

References

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