UMB298 | CBP/P300 inhibitor | Probechem Biochemicals

Chemical Structure : UMB298

CAS No.: 2266569-73-5

UMB298 (UMB-298)

Catalog No.: PC-26728Not For Human Use, Lab Use Only.

UMB298 is a potent, selective CBP/P300 inhibitor with IC50 of 72 nM (CBP), Kd of 315 nM and 215 nM for CBP and EP300, shows 72-fold selectivity over BRD4.

Packing	Price	Stock
5 mg	$128	In stock
10 mg	$198	In stock
25 mg	$348	In stock
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Biological Activity

UMB298 is a potent, selective CBP/P300 inhibitor with IC50 of 72 nM (CBP), Kd of 315 nM and 215 nM for CBP and EP300, shows 72-fold selectivity over BRD4.
UMB298 inhibits MOLM13 cell growth with IC50 of 1.74 uM, reduces the H3K27ac level and causes MYC depletion.

Physicochemical Properties

M.Wt	479.02
Formula	C27H31ClN4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-Chloro-4-methoxyphenethyl)-N-cyclohexyl-7-(3,5-dimethylisoxazol-4-yl)imidazo[1,2-a]pyridin-3-amine

References

1. Alex Muthengi, et al. J Med Chem. 2021 May 13;64(9):5787-5801.

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UMB298 (UMB-298)

Biological Activity

Physicochemical Properties

References

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