Chemical Structure : DUX4 inhibitor C06
CAS No.:
1166393-85-6
DUX4 inhibitor C06
Catalog No.: PC-27090Not For Human Use, Lab Use Only.
DUX4 inhibitor C06 is a potent, specific repressor of DUX4 and DUX4 target gene expression, exhibits binding to BAZ1A in vitro, also inhibits multiple kinases, including p38α, an upstream activator of DUX4.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DUX4 inhibitor C06 is a potent, specific repressor of DUX4 and DUX4 target gene expression, exhibits binding to BAZ1A in vitro, also inhibits multiple kinases, including p38α, an upstream activator of DUX4.
C06 exhibited a clear dose dependent repression of DUX4-fl and its downstream targets, with IC50s of 23.78 nM for DUX4, 22.18 nM for
MBD3L2, and 21.89 nM for TRIM43.
C06 inhibits p38α signaling in differentiated FSHD myocytes with an IC50 ~4.3X higher than losmapimod.
C06 returns the DUX4 gene expression signature to a healthier profile without major effects on the muscle transcriptome in FSHD myocytes.
Physicochemical Properties
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M.Wt
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445.53
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Formula
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C24H27N7O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(3-((pyridin-3-yloxy)methyl)-1H-pyrazol-5-yl)urea
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References
1. Chang N, et al. Sci Rep. 2026 Jun 16. doi: 10.1038/s41598-026-57734-5.
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