TAF1(2) inhibitor 23 | TAF1(2) inhibitor

Chemical Structure : TAF1(2) inhibitor 23

TAF1(2) inhibitor 23 (TAF1(2) bromodomain inhibitor)

Catalog No.: PC-72707Not For Human Use, Lab Use Only.

TAF1(2) inhibitor 23 is a potent and selective TAF1(2) bromodomain inhibitor with pKi of 9.1, >5000-fold selective over BRD4(1), >50-fold selectivity over the broader bromodomains.

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Biological Activity

TAF1(2) inhibitor 23 is a potent and selective TAF1(2) bromodomain inhibitor with pKi of 9.1, >5000-fold selective over BRD4(1), >50-fold selectivity over the broader bromodomains.

Physicochemical Properties

M.Wt	447.487
Formula	C22H27F2N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	8-((1-(3-amino-2,2-difluoropropanoyl)piperidin-4-yl)amino)-5-(3,6-dihydro-2H-pyran-4-yl)-3-methyl-1,7-naphthyridin-2(1H)-one

References

1. Clegg MA, et al. ACS Med Chem Lett. 2021 Aug 3;12(8):1308-1317.

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TAF1(2) inhibitor 23 (TAF1(2) bromodomain inhibitor)

Biological Activity

Physicochemical Properties

References

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