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TAF1(2) inhibitor 23

Chemical Structure : TAF1(2) inhibitor 23

CAS No.: 2986960-78-3

TAF1(2) inhibitor 23 (TAF1(2) bromodomain inhibitor)

Catalog No.: PC-72707Not For Human Use, Lab Use Only.

TAF1(2) inhibitor 23 is a potent and selective TAF1(2) bromodomain inhibitor with pKi of 9.1, >5000-fold selective over BRD4(1), >50-fold selectivity over the broader bromodomains.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TAF1(2) inhibitor 23 is a potent and selective TAF1(2) bromodomain inhibitor with pKi of 9.1, >5000-fold selective over BRD4(1), >50-fold selectivity over the broader bromodomains.

    Physicochemical Properties

    M.Wt 447.487
    Formula C22H27F2N5O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    8-((1-(3-amino-2,2-difluoropropanoyl)piperidin-4-yl)amino)-5-(3,6-dihydro-2H-pyran-4-yl)-3-methyl-1,7-naphthyridin-2(1H)-one

    References

    1. Clegg MA, et al. ACS Med Chem Lett. 2021 Aug 3;12(8):1308-1317.

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