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Chemical Structure : BI-7190
Catalog No.: PC-20122Not For Human Use, Lab Use Only.
BI-7190 (BI 7190) is a potent, selective chemical probe targeting the bromodomain of BPTF with binding Kd of 3.5 nM.
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BI-7190 (BI 7190) is a potent, selective chemical probe targeting the bromodomain of BPTF with binding Kd of 3.5 nM.
BI-7190 shows high binding affinity for bromodomain BPTF with Kd of 131 nM in ITC assays.
BI-7190 shows decreased the affinity for BRD9 (Kd=18.4 nM).
BI-7190 showed only weak cellular target engagement against the off-target bromodomains.
BI-7190 (1 uM) induced minor transcriptional modulation in NCI-H1437 cells over 120 h, including CLCF1, CLMP, and CLSPN.
BI-7190 is a suitable tool compound for in vivo efficacy and mode-of-action studies, as well as for PROTAC design.
| M.Wt | 381.52 | |
| Formula | C23H31N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Martinelli P, et al. ChemMedChem. 2023 Jan 17:e202200686.
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