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Chemical Structure : L-Moses dihydrochloride
CAS No.: 2079885-05-3
Catalog No.: PC-20178Not For Human Use, Lab Use Only.
L-Moses dihydrochloride (L-45) is a potent, selective, and cell-active PCAF (KAT2B) bromodomain inhibitor with Ki of 47 nM in HTRF assays, >4,500-fold selectivity over BRD4.
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|---|---|---|---|
| 5 mg | $398 | In stock | |
| 10 mg | $588 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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L-Moses dihydrochloride (L-45) is a potent, selective, and cell-active PCAF (KAT2B) bromodomain inhibitor with Ki of 47 nM in HTRF assays, >4,500-fold selectivity over BRD4.
L Moses disrupts PCAF-Brd histone H3.3 interaction in cells using a nanoBRET assay, shows high selectivity for PCAF and GCN5 bromodomain (Kd=600 nM).
L Moses shows no observable cytotoxicity in PBMCs, good cell-permeability, and metabolic stability in human and mouse liver microsomes.
| M.Wt | 433.38 | |
| Formula | C21H26Cl2N6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(1S,2S)-N1,N1-dimethyl-N2-(3-methyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yl)-1-phenylpropane-1,2-diamine dihydrochloride |
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1. Moustakim M, et al. Angew Chem Int Ed Engl. 2017 Jan 16;56(3):827-831.
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