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Chemical Structure : Tafbromin
Catalog No.: PC-22395Not For Human Use, Lab Use Only.
Tafbromin is a selective inhibitor of TAF1 bromodomain by binding to the second bromodomain (TAF1(2)) with KD of 260 nM, inhibits Hh pathway-dependent osteoblast differentiation.
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Tafbromin is a selective inhibitor of TAF1 bromodomain by binding to the second bromodomain (TAF1(2)) with KD of 260 nM, inhibits Hh pathway-dependent osteoblast differentiation.
Tafbromin displays no significant binding affinity to BRD7, BRD9, BRPF1 andTRIM24 (KD>10 uM).
Tafbromin inhibits Purmorphamine-induced osteoblast differentiation by modulating canonical Hh signaling and this activity is cell-type dependent and does not involve SMO binding.
Tafbromin does not inhibit Wnt and BMP-induced reporter geneexpression.
Tafbromin reduced the expression of Gli1 and Ptch1 in C3H10T1/2 cells by approximately 75% at a concentration of 5 uM.
Tafbromin is a better selective TAF1 bromodomain 2 ligand compared with CeMMEC1, BAY-299 and GNE-371.
| M.Wt | 393.46 | |
| Formula | C23H24FN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Patil S, et al. Angew Chem Int Ed Engl. 2024 May 27:e202404645.
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