Chemical Structure : SR-C-107 (R)
CAS No.:
SR-C-107 (R)
(SR-C-107 R-form)
Catalog No.: PC-23412Not For Human Use, Lab Use Only.
SR-C-107 (R) is a highly potent YEATS domain-containing protein ENL (Eleven-Nineteen-Leukemia) with IC50 of 40 nM, binding KD of 144 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SR-C-107 (R) is a highly potent YEATS domain-containing protein ENL (Eleven-Nineteen-Leukemia) with IC50 of 40 nM, binding KD of 144 nM.
SR-C-107 (R) exhibits outstanding antiproliferative effects in MOLM-13 and MV4-11 cells, with CC50 values of 1.25 and 0.81 μM, respectively.
SR-C-107 (R) 1 μM demonstrates strong inhibition of cell proliferation for MOLM-13 and MV4-11, with approximately 90% and 70% inhibition for MOLM-13 and MV4-11 cells, respectively.
SR-C-107 (R) specifically engages with ENL within live cells, SR-C-107 (R) (<1 uM) effectively suppress the expression of ENL target genes, including HOXA9, HOXA10, MEIS1, MYB and MYC, in MOLM-13 and MV4-11 cells.
SR-C-107 (R) at 200 mg/kg effectively exihibits tumor growth inhibition in MOML-13 xenografted mice.
Physicochemical Properties
|
M.Wt
|
389.46
|
|
Formula
|
C21H23N7O
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(R)-N-(2-((2-isopropylazetidin-1-yl)methyl)-1H-pyrrolo[3,2-c]pyridin-6-yl)-[1,2,4]triazolo[4,3-a]pyridine-6-carboxamide
|
References
1. Guo XS, et al. J Med Chem. 2024 Nov 12. doi: 10.1021/acs.jmedchem.4c01337.
Contact Us
sales@probechem.com
