Chemical Structure : SR-C-107 (R)
CAS No.:
SR-C-107 (R)
(SR-C-107 R-form)
Catalog No.: PC-23412Not For Human Use, Lab Use Only.
SR-C-107 (R) is a highly potent YEATS domain-containing protein ENL (Eleven-Nineteen-Leukemia) with IC50 of 40 nM, binding KD of 144 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SR-C-107 (R) is a highly potent YEATS domain-containing protein ENL (Eleven-Nineteen-Leukemia) with IC50 of 40 nM, binding KD of 144 nM.
SR-C-107 (R) exhibits outstanding antiproliferative effects in MOLM-13 and MV4-11 cells, with CC50 values of 1.25 and 0.81 μM, respectively.
SR-C-107 (R) 1 μM demonstrates strong inhibition of cell proliferation for MOLM-13 and MV4-11, with approximately 90% and 70% inhibition for MOLM-13 and MV4-11 cells, respectively.
SR-C-107 (R) specifically engages with ENL within live cells, SR-C-107 (R) (<1 uM) effectively suppress the expression of ENL target genes, including HOXA9, HOXA10, MEIS1, MYB and MYC, in MOLM-13 and MV4-11 cells.
SR-C-107 (R) at 200 mg/kg effectively exihibits tumor growth inhibition in MOML-13 xenografted mice.
Physicochemical Properties
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M.Wt
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389.46
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Formula
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C21H23N7O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-N-(2-((2-isopropylazetidin-1-yl)methyl)-1H-pyrrolo[3,2-c]pyridin-6-yl)-[1,2,4]triazolo[4,3-a]pyridine-6-carboxamide
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References
1. Guo XS, et al. J Med Chem. 2024 Nov 12. doi: 10.1021/acs.jmedchem.4c01337.
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