Zavabresib (PLX2853, OPN-2853) | BET inhibitor

Chemical Structure : Zavabresib

Zavabresib (PLX2853, PLX-2853, OPN-2853, OPN2853)

Catalog No.: PC-25104Not For Human Use, Lab Use Only.

Zavabresib (PLX2853, OPN-2853) is a potent BET inhibitor with anticancer activity, inhibits prostate cancer cell growth with IC50 of 0.043 and 0.034 μM against LNCaP and 22Rv1 cells, respectively.

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Biological Activity

Zavabresib (PLX2853, OPN-2853) is a potent BET inhibitor with anticancer activity, inhibits prostate cancer cell growth with IC50 of 0.043 and 0.034 μM against LNCaP and 22Rv1 cells, respectively.

Physicochemical Properties

M.Wt	515.57
Formula	C31H25N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(1-(1,1-di(pyridin-2-yl)ethyl)-6-(3,5-dimethylisoxazol-4-yl)-1H-pyrrolo[3,2-b]pyridin-3-yl)benzoic acid

References

1. Patent US20170081326 A1.

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Zavabresib (PLX2853, PLX-2853, OPN-2853, OPN2853)

Biological Activity

Physicochemical Properties

References

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