AZ3146 | Mps1 inhibitor | Probechem Biochemicals

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Chemical Structure : AZ3146

AZ3146 (AZ-3146)

Catalog No.: PC-22995Not For Human Use, Lab Use Only.

AZ3146 is a potent selective Mps1 inhibitor with IC50 of 35 nM against human Mps1Cat.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AZ3146 is a potent selective Mps1 inhibitor with IC50 of 35 nM against human Mps1Cat.
AZ3146 only inhibits FAK, JNK1, JNK2, and KIT.
AZ3146 compromises spindle assembly checkpoint (SAC) function and inhibits Mad2 localization.
AZ3146 inhibits kinetochore recruitment of O-Mad2.

Physicochemical Properties

M.Wt	452.56
Formula	C24H32N6O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9H)-one

References

1. Hewitt L, et al. J Cell Biol. 2010 Jul 12;190(1):25-34.

2. Gurden MD, et al. Cancer Res. 2015 Aug 15;75(16):3340-54.

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AZ3146 (AZ-3146)

Biological Activity

Physicochemical Properties

References

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