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Chemical Structure : AZ6197
Catalog No.: PC-35338Not For Human Use, Lab Use Only.
AZ6197 (AZ-6197) is a potent, selective, reversible inhibitor of ERK1/2 with IC50 of <0.3 nM (ERK2), inhibits pERK/pRSK with IC50 of 12/62 nM in A375 cells, respectively.
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AZ6197 (AZ-6197) is a potent, selective, reversible inhibitor of ERK1/2 with IC50 of <0.3 nM (ERK2), inhibits pERK/pRSK with IC50 of 12/62 nM in A375 cells, respectively; demonstrates in vivo antitumor efficacy.
| M.Wt | 442.527 | |
| Formula | C24H26N8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ward RA, et al. J Med Chem. 2017 Apr 27;60(8):3438-3450.
2. Decaudin D, et al. Oncotarget. 2018 Apr 24;9(31):21674-21686.
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