AZ67 is a potent, highly selective small molecule PFKFB3 inhibitor with IC50 of 18 nM, reduces cellular levels of F2,6BP with IC50 of 0.51 uM.
AZ67 prevents the NADPH oxidation, redox stress and apoptotic cell death caused by the activation of glycolysis triggered upon excitotoxic and oxygen-glucose deprivation/reoxygenation models in mouse primary neurons.
In vivo administration of AZ67 to mice significantly alleviated the motor discoordination and brain infarct injury in the middle carotid artery occlusion ischemia/reperfusion model.
AZ67 prevented the neuronal death triggered by the Alzheimer's disease-related peptide Aß25-35.
AZ67 did not decrease lactate production in endothelial cells (ECs), nor ATP levels, but exhibited good inhibitory efficacy in the tube-formation assay.
AZ67 demonstrated significant inhibition of angiogenesis in vivo.
