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Chemical Structure : AZ960
CAS No.: 905586-69-8
Catalog No.: PC-42571Not For Human Use, Lab Use Only.
AZ960 is a potent, selective JAK2 inhibitor with Ki of 0.45 nM, IC50 of <3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg (Free Sample) | $28 | In stock | |
| 5 mg | $148 | In stock | |
| 10 mg | $238 | In stock | |
| 25 mg | $388 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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AZ960 is a potent, selective JAK2 inhibitor with Ki of 0.45 nM, IC50 of <3 nM.
AZ960 displays 3-fold selectivity over JAK3 (IC50=9 nM).
AZ960 blocks STAT5 phosphorylation and potently inhibits cell proliferation (GI50=25 nM) in TEL-JAK2 driven Ba/F3 cells, blocks BCL-XL, PIM1 and PIM2 mRNA expression and induces apoptosis; also induces growth arrest and apoptosis in adult T-cell leukemia cells.
AZ960 also inhibits parasite Trypanosoma brucei ERK8 (Ki=1.25 uM) with antiparasitic activity (IC50=120nM).
| M.Wt | 354.3566464 | |
| Formula | C18H16F2N6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
3-Pyridinecarbonitrile, 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]- |
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1. Gozgit JM, et al. J Biol Chem. 2008 Nov 21;283(47):32334-43.
2. Yang J, et al. Mol Cancer Ther. 2010 Dec;9(12):3386-95.
3. Valenciano AL, et al. Bioorg Med Chem. 2016 Oct 1;24(19):4647-4651.
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