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Chemical Structure : AZD-1480
CAS No.: 935666-88-9
Catalog No.: PC-42438Not For Human Use, Lab Use Only.
A potent, selective, ATP competitive JAK2 inhibitor with Ki of 0.26 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $64 | In stock | |
| 50 mg | $160 | In stock | |
| 100 mg | $288 | In stock | |
| 200 mg | Get quote |
Bulk size, bulk discount!
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A potent, selective, ATP competitive JAK2 inhibitor with Ki of 0.26 nM; demonstrates significant JAK2 selectivity over JAK3 and marginal selectivity over JAK1; blocks STAT3 phosphorylation in a panel of human solid tumor cell lines, potently inhibits the growth of the TEL-Jak2 cell line (GI50=60 nM); suppresses the growth of human solid tumor xenografts harboring persistent Stat3 activity.
Liver Cancer
Phase 1 Discontinued
| M.Wt | 348.766 | |
| Formula | C14H14ClFN8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,4-Pyrimidinediamine, 5-chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)- |
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1. Hedvat M, et al. Cancer Cell. 2009 Dec 8;16(6):487-97.
2. Ioannidis S, et al. J Med Chem. 2011 Jan 13;54(1):262-76.
3. Scuto A, et al. Leukemia. 2011 Mar;25(3):538-50.
4. Xin H, et al. Cancer Res. 2011 Nov 1;71(21):6601-10.
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