AZD-1480 (AZD1480) is a potent, selective, ATP competitive JAK2 inhibitor with Ki of 0.26 nM.
AZD-1480 demonstrates significant JAK2 selectivity over JAK3 and marginal selectivity over JAK1.
AZD-1480 blocks STAT3 phosphorylation in a panel of human solid tumor cell lines, potently inhibits the growth of the TEL-Jak2 cell line (GI50=60 nM).
AZD-1480 suppresses the growth of human solid tumor xenografts harboring persistent Stat3 activity.
