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Chemical Structure : AZD-5423
CAS No.: 1034148-04-3
Catalog No.: PC-20260Not For Human Use, Lab Use Only.
AZD-5423 (AZD5423) is a potent, nonsteroidal, selective glucocorticoid receptor modulator with IC50 of 49 pM for inhibition of AP-1 mediated transcription.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | $858 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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AZD-5423 (AZD5423) is a potent, nonsteroidal, selective glucocorticoid receptor modulator with IC50 of 49 pM for inhibition of AP-1 mediated transcription.
AZD-5423 displays a potent inhibition of lung edema in a rat model of allergic airway inflammation following dry powder inhalation combined with a moderate systemic GR-effect.
AZD5423 also is potent RIPK3 inhibitor, strongly inhibits activation of RIPK3, and MLKL phosphorylation upon cisplatin-, hypoxia/reoxygenation (H/R)- and TNF-α stimuli as compared with GSK872.
AZD5423 exerts effective protection against cisplatin- and ischemia/reperfusion (I/R)-induced AKI mouse model.
| M.Wt | 487.45 | |
| Formula | C25H21F4N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,2,2-trifluoro-N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-methoxyphenyl)propan-2-yl)acetamide |
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1. Gauvreau GM, et al. Am J Respir Crit Care Med. 2015 Jan 15;191(2):161-7.
2. Werkström V, et al. Basic Clin Pharmacol Toxicol. 2016 Dec;119(6):574-581.
3. Hemmerling M, et al. J Med Chem. 2017 Oct 26;60(20):8591-8605.
4. Xu CH, et al. Int Immunopharmacol. 2022 Nov;112:109262.
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