Catalog No.: PC-20260Not For Human Use, Lab Use Only.
AZD-5423 (AZD5423) is a potent, nonsteroidal, selective glucocorticoid receptor modulator with IC50 of 49 pM for inhibition of AP-1 mediated transcription.
AZD-5423 (AZD5423) is a potent, nonsteroidal, selective glucocorticoid receptor modulator with IC50 of 49 pM for inhibition of AP-1 mediated transcription.
AZD-5423 displays a potent inhibition of lung edema in a rat model of allergic airway inflammation following dry powder inhalation combined with a moderate systemic GR-effect.
AZD5423 also is potent RIPK3 inhibitor, strongly inhibits activation of RIPK3, and MLKL phosphorylation upon cisplatin-, hypoxia/reoxygenation (H/R)- and TNF-α stimuli as compared with GSK872.
AZD5423 exerts effective protection against cisplatin- and ischemia/reperfusion (I/R)-induced AKI mouse model.
