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AZD-7594

Chemical Structure : AZD-7594

CAS No.: 1196509-60-0

AZD-7594 (Velsecorat, AZD7594, AZ-13189620)

Catalog No.: PC-63143Not For Human Use, Lab Use Only.

AZD-7594 (Velsecorat, AZ-13189620) is a potent, nonsteroidal, selective glucocorticoid receptor modulator (SGRM) with binding IC50 of 0.9 nM, shows no affinity for AR, PR, MR and ERα/β.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZD-7594 (Velsecorat, AZ-13189620) is a potent, nonsteroidal, selective glucocorticoid receptor modulator (SGRM) with binding IC50 of 0.9 nM, shows no affinity for AR, PR, MR and ERα/β.
AZD-7594 demonstrates cell potentcy with IC50 of 55 nM (repression of AP-1 dependent transcription), inhibits LPS-stimulated TNF-α production in human PBMC with IC50 0.43 nM.
AZD-7594 potently inhibits lung edema in a rat model of allergic airway inflammation with inhaled EC50 of 130 uM/Kg.

Physicochemical Properties

M.Wt 606.627
Formula C32H32F2N4O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(5-((1R,2S)-2-(2,2-difluoropropanamido)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)propoxy)-1H-indazol-1-yl)-N-((R)-tetrahydrofuran-3-yl)benzamide

References

1. Hemmerling M, et al. J Med Chem. 2017 Oct 26;60(20):8591-8605.

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