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AZD-7762

Chemical Structure : AZD-7762

CAS No.: 860352-01-8

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AZD-7762 (AZD7762;AZD 7762)

Catalog No.: PC-42769Not For Human Use, Lab Use Only.

AZD-7762 (AZD7762) is a potent and selective inhibitor of Chk1/2 with IC50 of 5 nM.

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5 mg $78 In stock
10 mg $118 In stock
25 mg $188 In stock
50 mg $298 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZD-7762 (AZD7762) is a potent and selective inhibitor of Chk1/2 with IC50 of 5 nM.
AZD-7762 shows less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.
AZD-7762 enhances the radiosensitivity of mutated p53 tumor cell lines and HT29 xenografts.

Physicochemical Properties

M.Wt 362.4218
Formula C17H19FN4O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Thiophenecarboxamide, 3-[(aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-

References

1. Zabludoff SD, et al. Mol Cancer Ther. 2008 Sep;7(9):2955-66.

2. Mitchell JB, et al. Clin Cancer Res. 2010 Apr 1;16(7):2076-84.

3. Morgan MA, et al. Cancer Res. 2010 Jun 15;70(12):4972-81.

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