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Chemical Structure : AZD1208
CAS No.: 1204144-28-4
Catalog No.: PC-22796Not For Human Use, Lab Use Only.
AZD1208 is a potent and selective, ATP-competitive pan-Pim kinase inhibitor with IC50 of 0.4/5.0/1.9 nM for Pim-1/2/3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | $368 | In stock | |
| 250 mg | Get quote |
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AZD1208 is a potent and selective, ATP-competitive pan-Pim kinase inhibitor with IC50 of 0.4/5.0/1.9 nM for Pim-1/2/3, respectively.
AZD1208 has Ki values of 0.1 nM for Pim-1, 1.92 nM for Pim-2, and 0.4 nM for Pim-3.
AZD1208 inhibits AML cell-line growth and can induce cell-cycle arrest and apoptosis, accompanied by a dose-dependent reduction in phosphorylation of Bcl-2 antagonist of cell death, 4EBP1, p70S6K, and S6.
AZD1208 potently inhibits the level of pBAD with IC50 of 10 nM for Pim-1, 151 nM for Pim-2, and 102 nM for Pim-3in U2-OS cells.
AZD1208 (10 mg/kg or 30 mg/kg) inhibits the growth of MOLM-16 and KG-1a xenograft tumors in vivo.
| M.Wt | 379.48 | |
| Formula | C21H21N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R,Z)-5-((2-(3-Aminopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)methylene)thiazolidine-2,4-dione |
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1. Keeton EK,
2. Dakin LA, et al. Bioorg Med Chem Lett. 2012;22(14):4599–4604.
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